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desvenlafaxine will improve the level or result of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Keep track of. Desvenlafaxine inhibits CYP2D6; with higher desvenlafaxine doses (ie, four hundred mg) reduce the CYP2D6 substrate dose by up to fifty%; no dosage adjustment wanted with desvenlafaxine doses 7 consecutive days instant